About Cha2ds2 vasc score calculator
Compared to ACEF and CHA2DS2-VASc, provided the best discriminative performance for the 30-day mortality (P=0.03 and PIn patients with unprotected LMCA, EuroSCORE II showed better discriminative performance than ACEF and CHA2DS2-VASc in short-term (P=0.051 and P in the long-term EuroSCORE II and ACEF were better than CHA2DS2-VASc (P both two model comparisons). In the subgroup of post-CABG patients, EuroSCORE II and ACEF provided moderate 30-day mortality discriminative performance, as opposed to poor CHA2DS2-VASc discrimination. In the long-term, all of the analysed CPMs provided acceptable discriminative performance.Pertinent conclusions. Author Response The study presents actual data with a lot of clinical implications.The present study analyses data collected retrospectively from the BIA-LM Registry.In brief, the registry is a single-centre database of LMCA PCI performed in the Department of Invasive Cardiology, Medical University of Bialystok, Poland analyzing patients referred for surgical or conservative treatment during a period of 4 years, from 12.27.2008 to 02.21.2022.A final cohort of 851 individuals undergoing LMCA angioplasty were included into analysis. All analysed scores were recalculated for every patient enrolled in the study: EuroSCORE II using the interactive calculator (available at CHA2DS2-VASc as sum of 1 point for diagnosis of heart failure, hypertension, age between 65-74 years, diabetes mellitus, vascular disease, female gender and 2 points for age ≥75 years and prior stroke or transient ischemic attack, and ACEF as age divided by ejection fraction plus one if serum creatinine was ≥2 mg/dl.One mention I have concerning CHA2DS2-VASC Score. Since 30 august 2024 is not actual. After 2024ESC Guideline for atrial fibrillation, CHA2DS2-VA Score is used instead of CHA2DS2-VASc. = Congestive heart failure, hypertension, age ≥75 years (2 points), diabetes mellitus, prior stroke/transient ischaemic attack/arterial thromboembolism (2 points), vascular disease, age 65–74 years (score)Analyses were performed for the overall population, patients with unprotected LMCA (i.e., with no previous CABG)
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And protected LMCA (patients with a history of previous CABG). Further calculations were performed based on the severity of CAD. Patients were divided into four subgroups: isolated LMCA narrowing, with additional 1-, 2- or 3-vessel disease (1-VD, 2-VD, 3-VD, respectively). The design of the study is very well conceived.In the overall cohort, EuroSCORE II as compared to ACEF and CHA2DS2-VASc, provided the best discriminative performance for the 30-day mortality (P=0.03 and PIn patients with unprotected LMCA, EuroSCORE II showed better discriminative performance than ACEF and CHA2DS2-VASc in short-term (P=0.051 and PPertinent conclusions.Reply: We thank for the kind words and remark regarding recent guidelines recommendations to use CHA2DS2-VA instead of CHA2DS2-VASc. To make our analysis up to date, we have now included CHADS-VA analyses in the manuscript. However, to remain maximal generalizability, we decided not to remove results investigating validation of CHA2DS2-VASc score – calculator widely used for the past 14 years.Now, readers can find information on the performance of four calculators in present manuscript.Changes: Please see changes in the Introduction, Methods, Results and Discussion section and new Figure 3 now included in the manuscript. Reviewer 3 Report Comments and Suggestions for AuthorsIn the study the authors established that EuroSCORE II showed good mortality prediction the short-term observation, its predicted risk should be interpreted with caution due to poor calibration. ACEF score and EuroSCORE II may be useful in long-term mortality prediction.Although the findings are impressive and practically useful, I would like to make some comments.1. The authors might discuss the patients-related factors incorporated into the EuroSCORE II, which had not been added to Table 1.2. ACEF score was developed for 30-day mortality after elective or emergency cardiac surgery, so it is not suitable for the long-term risk evaluation. Please, explaine this.3. CHA₂DS₂-VASc Score is avaiable for Atrial Fibrillation Stroke Risk,
